Tramadol works by binding to opioid receptors in the brain and spinal cord, which helps to block the transmission of pain signals and reduce the perception of pain. It also increases the levels of neurotransmitters like serotonin and norepinephrine in the brain, which can further help to alleviate pain. The duration of action of tramadol can vary depending on whether it is taken in immediate-release or extended-release formulations. Immediate-release tramadol typically starts working within an hour of taking it, with peak effects occurring within 2-3 hours. The effects of immediate-release tramadol usually last for about 4-6 hours.
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