Fildena 100 is a prescription pill that helps men achieve firm erections. Unlike Viagra, Sildenafil does not affect a man's sex organ size, and it helps men achieve an erection that lasts long enough to maintain it for a long time. It is recommended for men over 18 and is only available on a doctor's prescription.
Sildenafil is a prescription pill that helps lower blood pressure in the pulmonary arteries. This medicine reduces blood pressure in the lungs by reducing resistance to blood flow. In people with pulmonary hypertension, blood vessels in the lungs are narrow and tight, resulting in increased resistance to blood flow. Sildenafil reduces this resistance by increasing vasodilation. It decreases the activity of phosphodiesterase-5, which breaks down the compound cyclic guanosine monophosphate (GMP), which has a relaxing effect on blood vessels.
The pill is FDA-approved for the treatment of pulmonary hypertension. In addition, it is approved for the treatment of chronic thromboembolic pulmonary hypertension, right ventricular hypertrophy, and Raynaud's phenomenon. It is also being studied for its effectiveness in treating cerebrovascular diseases.
In a study of 12 patients with thromboembolic PH, Sildenafil reduced mPAP and PVRI. However, the study did not report any adverse effects on the patients. The medication is not recommended in patients with severe liver or kidney disease. It can also cause a vaso-occlusive crisis. However, Sildenafil is increasingly prescribed for PAH.
The effectiveness of Fildena in treating pulmonary hypertension was first shown in animal models. In a mouse model, it has already been shown to block the effect of hormones that increase blood pressure. It reduces the amount of force the heart uses to pump blood. Moreover, it has been shown to reverse the long-term effects of chronic high blood pressure.
Sildenafil works by inhibiting phosphodiesterase-5 (PDE5), a phosphodiesterase in the pulmonary vascular smooth muscle. Inhibition of PDE5 results in increased cGMP levels in the endothelial cells and relaxation of the vascular smooth muscle. This makes it an ideal pill for treating patients with endothelial dysfunction. It also has a selective action against PDEs 1-4.
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