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Tramadol is a synthetic opioid analgesic used to treat moderate to moderately severe pain. It acts on the central nervous system (CNS) to relieve pain and is available in immediate-release and extended-release formulations. Here’s a comprehensive overview of tramadol:

Mechanism of Action

Tramadol works by binding to the mu-opioid receptors in the brain, mimicking the action of natural pain-relieving chemicals (endorphins). Additionally, it inhibits the reuptake of neurotransmitters serotonin and norepinephrine, which also helps in pain relief.

Common Uses

Pain Management: Tramadol is prescribed for managing moderate to moderately severe pain from conditions such as surgery, injury, or chronic conditions like osteoarthritis.
Extended-Release Formulations: These are used for around-the-clock treatment of pain and should not be used on an as-needed basis.

Dosage and Administration

Forms: Available in oral tablets, capsules, and liquid forms.
Typical Dosages:
Immediate-Release: 50-100 mg every 4-6 hours as needed for pain. Maximum dose is typically 400 mg per day.
Extended-Release: 100 mg once daily, which can be increased by 100 mg every 5 days to a maximum of 300 mg per day.

Side Effects

Common Side Effects: Nausea, vomiting, dizziness, constipation, headache, drowsiness, and dry mouth.
Serious Side Effects: Seizures, serotonin syndrome (especially when taken with other serotonergic drugs), respiratory depression, and severe allergic reactions.
Dependence and Withdrawal: Long-term use can lead to physical dependence, and abrupt discontinuation can cause withdrawal symptoms such as agitation, anxiety, and flu-like symptoms.

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